Depression of Plasmodium falciparum dihydroorotate dehydrogenase activity in in vitro culture by tetracycline

• Main Authors: Phisit Prapunwattana, William J. O'Sullivan, Yongyuth Yuthavong
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15494

The activity of Plasmodium falciparum dihydroorotate dehydrogenase, a particulate, electron transport-linked enzyme involved in de novo pyrimidine synthesis, was depressed when the parasite was cultured in the presence of a therapeutic concentration of tetracycline over a 96 h period. There was no d...