Azadirachtin derivatives from seed kernels of Azadirachta excelsa

Azadirachtin derivatives from seed kernels of Azadirachta excelsa

Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11α-azadirachtin H (7), 11β-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were establ...

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Bibliographic Details
Main Authors: Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Thirada Prajuabsuk, Sanha Panichajakul, Piyanan Panyamee, Samran Prabpai, Palangpon Kongsaeree
Other Authors: Khon Kaen University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/16322
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Institution: Mahidol University
Description
Summary:Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11α-azadirachtin H (7), 11β-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 μg/g body weight, in 92 h. © 2005 American Chemical Society and American Society of Pharmacognosy.

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