Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression

• Main Authors: Jong So Kim, Steven L. Coon, Seth Blackshaw, Constance L. Cepko, Morten Møller, Sujira Mukda, Wan Qian Zhao, Clivel G. Charlton, David C. Klein
• Other Authors: National Institute of Child Health and Human Development
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16385
• Institution: Mahidol University

(S)-Adenosylmethionine (SAM) is a critical element of melatonin synthesis as the methyl donor in the last step of the pathway, the O-methylation of N-acetyl 5-hydroxytryptamine by hydroxyindole-O-methyltransferase. The activity of the enzyme that synthesizes SAM, methionine adenosyltransferase (MAT)...