Efficacy of DB289 in Thai patients with plasmodium vivax or acute, uncomplicated Plasmodium falaparum infections

• Main Authors: Patrick Yeramian, Steven R. Meshnick, Srivicha Krudsood, Kobsiri Chalermrut, Udomsak Silachamroon, Noppadon Tangpukdee, James Allen, Reto Brun, Jesse J. Kwiek, Richard Tidwell, Somchai Looareesuwan
• Other Authors: Immtech International Inc.
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16906
• Institution: Mahidol University

Background. DB289 is the orally active prodrug of the diamidine DB75, which was developed for the treatment of human African trypanosomiasis. Methods. We tested the safety and efficacy of DB289 for the treatment of Plasmodium vivax and acute, uncomplicated P. falciparum infections in an open-label p...