Lupane derivatives from Lophopetalum wallichii with farnesyl protein transferase inhibitory activity

• Main Authors: Sonja Sturm, Roberto R. Gil, Hee Byung Chai, Olipa D. Ngassapa, Thawatchai Santisuk, Vichai Reutrakul, Anne Howe, Marcia Moss, Jeffrey M. Besterman, Shi Lin Yang, John E. Farthing, R. Murray Tait, Jane A. Lewis, Melanie J. O'Neill, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn
• Other Authors: University of Illinois at Chicago
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/17540
• Institution: Mahidol University

Chloroform-soluble extracts of the stems and of the mixed stems and stem bark of Lophopetalum wallichii were found to be inhibitory in a farnesyl protein transferase (FPTase) bioassay system. During the course of activity- guided fractionation, the known lupane-type triterpenes, ochraceolide A (1),...