Assessment of pfmdr1 gene copy number by tandem competitive polymerase chain reaction

• Main Authors: Ric Price, Grant Robinson, Alan Brockman, Alan Cowman, Sanjeev Krishna
• Other Authors: St George's University of London
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/17898
• Institution: Mahidol University

The pfmdr1 gene encodes a Plasmodium falciparum homologue of the human P-glycoprotein expressed on the surface of the parasite food vacuole. Variation in copy number and specific codon mutations of pfmdr1 have been implicated in the development of parasite resistance to antimalarial drugs. We descri...