Cross-protective capacity of Japanese Encephalitis (JE) vaccines against circulating Heterologous JE Virus genotypes

• Main Authors: Erra, Elina O., Askling, Helena Hervius, Sutee Yoksan, Rombo, Lars, Riutta, Jukka, Vene, Sirkka, Lindquist, Lars, Vapalahti, Olli, Anu Kantele
• Other Authors: Mahidol University. Institute of Molecular Biosciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Japanese encephalitis; vaccine; traveler; crossreactive immunity; flavivirus; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/1820
• Institution: Mahidol University

Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I–IV...