High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency

• Main Authors: Caterina I. Fanello, Corine Karema, Pamela Avellino, Germana Bancone, Aline Uwimana, Sue J. Lee, Umberto d'Alessandro, David Modiano
• Other Authors: Nuffield Department of Clinical Medicine
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18655
• Institution: Mahidol University

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant properties. Methods: The safety of chlorprogua...