Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo

Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo

Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2. From a panel of 11 Fabs recovered by different panning strategies, three highly potent neutraliz...

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Bibliographic Details
Main Authors: Ana P. Goncalvez, Cheng Hsin Chien, Kamolchanok Tubthong, Inna Gorshkova, Carrie Roll, Olivia Donau, Peter Schuck, Sutee Yoksan, Sy Dar Wang, Robert H. Purcell, Ching Juh Lai
Other Authors: National Institute of Allergy and Infectious Diseases
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/18725
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/18725

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