Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo

• Main Authors: Ana P. Goncalvez, Cheng Hsin Chien, Kamolchanok Tubthong, Inna Gorshkova, Carrie Roll, Olivia Donau, Peter Schuck, Sutee Yoksan, Sy Dar Wang, Robert H. Purcell, Ching Juh Lai
• 其他作者: National Institute of Allergy and Infectious Diseases
• 格式: Article
• 出版: 2018
• 主題: Agricultural and Biological Sciences; Immunology and Microbiology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/18725

Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2. From a panel of 11 Fabs recovered by different panning strategies, three highly potent neutraliz...