L-glutamate enhances methylmercury toxicity by synergistically increasing oxidative stress

• Main Authors: Sirirat Amonpatumrat, Hiroyuki Sakurai, Pattama Wiriyasermkul, Narakorn Khunweeraphong, Shushi Nagamori, Hidekazu Tanaka, Pawinee Piyachaturawat, Yoshikatsu Kanai
• Other Authors: Kyorin University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18826
• Institution: Mahidol University

Methylmercury (MeHg) is a well-known environmental toxicant. With its lipophilic nature and high reactivity to sulfhydryl groups, it is widely distributed and accumulated in the body to damage cells. Oxidative stress is proposed as a major mechanism underlying the cytotoxic action of MeHg. In the pr...