How should we use information about HWE in the meta-analyses of genetic association studies?

Background: It is often recommended that control groups in meta-analyses of genetic association studies are checked for Hardy-Weinberg equilibrium (HWE) as a surrogate for assessing study quality. However, tests for HWE have low power and there is currently no consensus about how to handle studies t...

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Bibliographic Details
Main Authors: Cosetta Minelli, John R. Thompson, Keith R. Abrams, Ammarin Thakkinstian, John Attia
Other Authors: National Heart and Lung Institute
Format: Article
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/19774
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Institution: Mahidol University