Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

• Main Authors: Chongdee Nilanonta, Masahiko Isaka, Prasat Kittakoop, Srisuda Trakulnaleamsai, Morakot Tanticharoen, Yodhathai Thebtaranonth
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20068

Precursor-directed biosynthesis of beauvericin analogs, cyclohexadepsipeptide antibiotics, was investigated using the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Feeding L-isoleucine or D-alloisoleucine in liquid medium led to the enhanced production of beauvericin A and beauvericin B t...