Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

Precursor-directed biosynthesis of beauvericin analogs, cyclohexadepsipeptide antibiotics, was investigated using the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Feeding L-isoleucine or D-alloisoleucine in liquid medium led to the enhanced production of beauvericin A and beauvericin B t...

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Bibliographic Details
Main Authors: Chongdee Nilanonta, Masahiko Isaka, Prasat Kittakoop, Srisuda Trakulnaleamsai, Morakot Tanticharoen, Yodhathai Thebtaranonth
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/20068
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Institution: Mahidol University
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Summary:Precursor-directed biosynthesis of beauvericin analogs, cyclohexadepsipeptide antibiotics, was investigated using the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Feeding L-isoleucine or D-alloisoleucine in liquid medium led to the enhanced production of beauvericin A and beauvericin B together with beauvericin and a missing analog, beauvericin C. Feeding experiments with D-isoleucine or L-alloisoleucine resulted in the production of diastereomers of beauvericins A, B and C, named allobeauvericins A, B and C, respectively. © 2002 Elsevier Science Ltd. All rights reserved.

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