A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

• Main Authors: Paul N. Newton, Hung Thai Le, Quoc Tip Nguyen, Jennifer M. Short, Wirongrong Chierakul, Adul Rajanuwong, Punnee Pitisuttithum, Sanchai Chasombat, Benjaluck Phonrat, Wirach Maek-A-Nantawat, Reungsilp Teaunadi, David G. Lalloo, Nicholas J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20358

We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of ≥200 mm H2O. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bi...