8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic...

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Main Authors: Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Other Authors: Center of Data Mining and Biomedical Informatics
Format: Article
Language:English
Published: 2014
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/2075
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Institution: Mahidol University
Language: English
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spelling th-mahidol.20752023-04-12T15:24:42Z 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications Veda Prachayasittikul Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul Center of Data Mining and Biomedical Informatics Department of Clinical Microbiology and Applied Technology Metal binding compound Antineurodegenerative Anticancer Aantidiabetic Multifunctional actions Structure–activity relationships Open Access article Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure–activity relationships. 2014-03-24T06:43:31Z 2017-06-20T16:08:13Z 2014-03-24T06:43:31Z 2017-06-20T16:08:13Z 2013 Article Drug Design, Development and Therapy. Vol.7, 2013, 1157-1178 https://repository.li.mahidol.ac.th/handle/123456789/2075 eng University Drug Design, Development and Therapy application/pdf
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
language English
topic Metal binding compound
Antineurodegenerative
Anticancer
Aantidiabetic
Multifunctional actions
Structure–activity relationships
Open Access article
spellingShingle Metal binding compound
Antineurodegenerative
Anticancer
Aantidiabetic
Multifunctional actions
Structure–activity relationships
Open Access article
Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
description Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure–activity relationships.
author2 Center of Data Mining and Biomedical Informatics
author_facet Center of Data Mining and Biomedical Informatics
Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
format Article
author Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
author_sort Veda Prachayasittikul
title 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
title_short 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
title_full 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
title_fullStr 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
title_full_unstemmed 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
title_sort 8-hydroxyquinolines: a review of their metal chelating properties and medicinal applications
publishDate 2014
url https://repository.li.mahidol.ac.th/handle/123456789/2075
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