8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

• Main Authors: Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
• Other Authors: Center of Data Mining and Biomedical Informatics
• Format: Article
• Language: English
• Published: 2014
• Subjects: Metal binding compound; Antineurodegenerative; Anticancer; Aantidiabetic; Multifunctional actions; Structure–activity relationships; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2075
• Institution: Mahidol University

Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic...