Insertion of common mutations into the human β-globin locus using GET Recombination and an EcoRI endonuclease counterselection cassette

• المؤلفون الرئيسيون: Duangporn Jamsai, Mikhail Nefedov, Kumaran Narayanan, Michael Orford, Suthat Fucharoen, Robert Williamson, Panos A. Ioannou
• مؤلفون آخرون: Royal Children's Hospital, Melbourne
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/20760
• المؤسسة: Mahidol University

A large number of mutations have been described in the human β-globin locus causing thalassemia or various hemoglobinopathies. However, only a very limited number of these mutations have been studied in animal model systems in the context of the human β-globin locus. We report here the use of the GE...