CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B

• Main Authors: Yuki Hitomi, Naoyuki Tsuchiya, Aya Kawasaki, Jun Ohashi, Takeshi Suzuki, Chieko Kyogoku, Toru Fukazawa, Sasitorn Bejrachandra, Usanee Siriboonrit, Dasnayanee Chandanayingyong, Puan Suthipinittharm, Betty P. Tsao, Hiroshi Hashimoto, Zen Ichiro Honda, Katsushi Tokunaga
• Other Authors: University of Tokyo
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21116
• Institution: Mahidol University

We previously reported association of FCGR2B-IIe232Thr with systemic lupus erythematosus (SLE) in three Asian populations. Because polymorphism of CD72, another inhibitory receptor of B cells, was associated with murine SLE, we identified human CD72 polymorphisms, tested their association with SLE a...