Enhanced sensitivity of detection of cytotoxic T lymphocyte responses to HIV type 1 proteins using an extended in vitro stimulation period for measuring effector function in volunteers enrolled in an ALVAC-HIV phase I/II prime boost vaccine trial in Thailand

• Main Authors: Wannee Kantakamalakul, Mark De Souza, Chitraporn Karnasuta, Arthur Brown, Sanjay Gurunathan, Deborah Birx, Prasert Thongcharoen, The Taveg
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21384

A phase I/II prime-boost vaccine trial in HIV-1-seronegative adults was conducted in Thailand using ALVAC-HIV (vCP1521) as a prime, boosting with either oligomeric gp160 TH023/LAI or Chiron HIV Thai subtype E (CM235) plus U.S. subtype B (SF2) gp120. Cytotoxic T lymphocyte (CTL) assays were conducted...