Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis
Background. 'Primary' osteoporosis has been associated with a high incidence of a renal acidification defect, incomplete renal tubular acidosis (iRTA). An acid loading test, to exclude the defect, has been recommended for inclusion in the work-up of osteoporosis. However, there is no commu...
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th-mahidol.214832018-07-24T10:46:28Z Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis Chatlert Pongchaiyakul Somnuek Domrongkitchaiporn Wasana Stitchantrakul La Or Chailurkit Rajata Rajatanavin Khon Kaen University Mahidol University Medicine Background. 'Primary' osteoporosis has been associated with a high incidence of a renal acidification defect, incomplete renal tubular acidosis (iRTA). An acid loading test, to exclude the defect, has been recommended for inclusion in the work-up of osteoporosis. However, there is no community-based study to confirm its utility. Method. A community-based survey was conducted in the Khon Kaen province, Thailand, between January and June, 2000. We randomly enrolled 361 apparently healthy adults, 146 men and 215 women, in this study. The bone mineral densities (BMDs) of the spine and femur were determined in all subjects. The diagnosis of iRTA was based on: normal serum electrolytes and one or both of first morning urinary pH >5.5 or the failure of an acid loading test to decrease it to >5.5. Dietary diaries, serum electrolyte tests and 24 h urine collections were obtained from all iRTA subjects. Results. There were 23 (6.4%) iRTA subjects in the population studied. The age, height, weight and calcium intake were comparable between iRTA and normal subjects, as were the BMDs of spine and femur. There was no difference between the two groups in the distributions of BMD with age for either area. Multiple regression analyses of the studied population demonstrated that age, body weight, duration of menopause and gender (only for the femoral neck) were independent variables that affected BMD. Conclusion. Incomplete distal renal tubular acidosis alone was not associated with lower bone mass in this cohort. It may nevertheless be valuable to monitor serum electrolytes and BMD in patients with iRTA due to their tendency to develop intermittent metabolic acidosis. © ERA-EDTA 2004; all rights reserved. 2018-07-24T03:46:28Z 2018-07-24T03:46:28Z 2004-12-01 Article Nephrology Dialysis Transplantation. Vol.19, No.12 (2004), 3029-3033 10.1093/ndt/gfh534 09310509 2-s2.0-11244281055 https://repository.li.mahidol.ac.th/handle/123456789/21483 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=11244281055&origin=inward |
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Medicine Chatlert Pongchaiyakul Somnuek Domrongkitchaiporn Wasana Stitchantrakul La Or Chailurkit Rajata Rajatanavin Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
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Background. 'Primary' osteoporosis has been associated with a high incidence of a renal acidification defect, incomplete renal tubular acidosis (iRTA). An acid loading test, to exclude the defect, has been recommended for inclusion in the work-up of osteoporosis. However, there is no community-based study to confirm its utility. Method. A community-based survey was conducted in the Khon Kaen province, Thailand, between January and June, 2000. We randomly enrolled 361 apparently healthy adults, 146 men and 215 women, in this study. The bone mineral densities (BMDs) of the spine and femur were determined in all subjects. The diagnosis of iRTA was based on: normal serum electrolytes and one or both of first morning urinary pH >5.5 or the failure of an acid loading test to decrease it to >5.5. Dietary diaries, serum electrolyte tests and 24 h urine collections were obtained from all iRTA subjects. Results. There were 23 (6.4%) iRTA subjects in the population studied. The age, height, weight and calcium intake were comparable between iRTA and normal subjects, as were the BMDs of spine and femur. There was no difference between the two groups in the distributions of BMD with age for either area. Multiple regression analyses of the studied population demonstrated that age, body weight, duration of menopause and gender (only for the femoral neck) were independent variables that affected BMD. Conclusion. Incomplete distal renal tubular acidosis alone was not associated with lower bone mass in this cohort. It may nevertheless be valuable to monitor serum electrolytes and BMD in patients with iRTA due to their tendency to develop intermittent metabolic acidosis. © ERA-EDTA 2004; all rights reserved. |
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Khon Kaen University |
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Khon Kaen University Chatlert Pongchaiyakul Somnuek Domrongkitchaiporn Wasana Stitchantrakul La Or Chailurkit Rajata Rajatanavin |
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Article |
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Chatlert Pongchaiyakul Somnuek Domrongkitchaiporn Wasana Stitchantrakul La Or Chailurkit Rajata Rajatanavin |
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Chatlert Pongchaiyakul |
title |
Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
title_short |
Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
title_full |
Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
title_fullStr |
Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
title_full_unstemmed |
Incomplete renal tubular acidosis and bone mineral density: A population survey in an area of endemic renal tubular acidosis |
title_sort |
incomplete renal tubular acidosis and bone mineral density: a population survey in an area of endemic renal tubular acidosis |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/21483 |
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1763497672230043648 |