Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats

• Main Authors: Danai Tiwawech, Ryohei Hasegawa, Yasushi Kurata, Masae Tatematsu, Masa Aki Shibata, Witaya Thamavit, Nobuyuki Ito
• Other Authors: Nagoya City University Medical School
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21986
• Institution: Mahidol University

Dose-dependent development of pre-neoplastk liver cell foci induced by 2-acetylaminofluorene (2-AAF) was investigated in relation to cell-proliferative activity. Male F344 rats were initially given a single i.p. injection of diethylnitrosamine (DEN, 200 mg/kg) and starting 2 weeks later received die...