Polymorphism of glutathione S-transferase Omega gene and risk of cancer
Polymorphic glutathione S-transferase (GST) genes causing variations in enzyme activity may influence individual susceptibility to cancer. Though polymorphisms have been reported in GSTO1 and GSTO2, their predisposition to cancer risk has not yet been explored. In this case control study, 28 cases o...
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th-mahidol.230402018-08-20T14:16:51Z Polymorphism of glutathione S-transferase Omega gene and risk of cancer Sujan Babu Marahatta Phaibul Punyarit Vajarabhongsa Bhudisawasdi Anucha Paupairoj Sopit Wongkham Songsak Petmitr Mahidol University Phramongkutklao College of Medicine Khon Kaen University Biochemistry, Genetics and Molecular Biology Medicine Polymorphic glutathione S-transferase (GST) genes causing variations in enzyme activity may influence individual susceptibility to cancer. Though polymorphisms have been reported in GSTO1 and GSTO2, their predisposition to cancer risk has not yet been explored. In this case control study, 28 cases of hepatocellular carcinoma, 30 cases of cholangiocarcinoma, 31 cases of colorectal cancer, 30 cases of breast cancer and 98 controls were compared for frequencies of GSTO1 and GSTO2 genotypes. The statistical analysis provided the support for the difference in genotypic distribution for GSTO1*A140D between hepatocellular carcinoma (OR 23.83, CI 95%: 5.07-127), cholangiocarcinoma (OR 8.5, CI 95%: 2.07-37.85), breast cancer (OR 3.71, CI 95%: 1.09-13.02) and control. With regards to GSTO2*N140D polymorphism, there was no difference in genotypic distribution between all the types of cancer and control. The study suggests that GSTO1*A140D polymorphism could play an important role as a risk factor for the development of hepatocellular carcinoma, cholangiocarcinoma and breast cancer. © 2005 Elsevier Ireland Ltd. All rights reserved. 2018-08-20T06:51:44Z 2018-08-20T06:51:44Z 2006-05-18 Article Cancer Letters. Vol.236, No.2 (2006), 276-281 10.1016/j.canlet.2005.05.020 03043835 2-s2.0-33646505097 https://repository.li.mahidol.ac.th/handle/123456789/23040 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33646505097&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Sujan Babu Marahatta Phaibul Punyarit Vajarabhongsa Bhudisawasdi Anucha Paupairoj Sopit Wongkham Songsak Petmitr Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
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Polymorphic glutathione S-transferase (GST) genes causing variations in enzyme activity may influence individual susceptibility to cancer. Though polymorphisms have been reported in GSTO1 and GSTO2, their predisposition to cancer risk has not yet been explored. In this case control study, 28 cases of hepatocellular carcinoma, 30 cases of cholangiocarcinoma, 31 cases of colorectal cancer, 30 cases of breast cancer and 98 controls were compared for frequencies of GSTO1 and GSTO2 genotypes. The statistical analysis provided the support for the difference in genotypic distribution for GSTO1*A140D between hepatocellular carcinoma (OR 23.83, CI 95%: 5.07-127), cholangiocarcinoma (OR 8.5, CI 95%: 2.07-37.85), breast cancer (OR 3.71, CI 95%: 1.09-13.02) and control. With regards to GSTO2*N140D polymorphism, there was no difference in genotypic distribution between all the types of cancer and control. The study suggests that GSTO1*A140D polymorphism could play an important role as a risk factor for the development of hepatocellular carcinoma, cholangiocarcinoma and breast cancer. © 2005 Elsevier Ireland Ltd. All rights reserved. |
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Mahidol University |
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Mahidol University Sujan Babu Marahatta Phaibul Punyarit Vajarabhongsa Bhudisawasdi Anucha Paupairoj Sopit Wongkham Songsak Petmitr |
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Article |
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Sujan Babu Marahatta Phaibul Punyarit Vajarabhongsa Bhudisawasdi Anucha Paupairoj Sopit Wongkham Songsak Petmitr |
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Sujan Babu Marahatta |
title |
Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
title_short |
Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
title_full |
Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
title_fullStr |
Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
title_full_unstemmed |
Polymorphism of glutathione S-transferase Omega gene and risk of cancer |
title_sort |
polymorphism of glutathione s-transferase omega gene and risk of cancer |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/23040 |
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1763487439948611584 |