β²-amino acids in the design of conformationally homogeneous cyclo-peptide scaffolds

• Main Authors: Anna S. Norgren, Frank Büttner, Samran Prabpai, Palangpon Kongsaeree, Per I. Arvidsson
• Other Authors: Uppsala Universitet
• Format: Article
• Published: 2018
• Subjects: Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23150
• Institution: Mahidol University

Herein, we report studies on the influence of chiral β2- amino acids in the design of conformationally homogeneous cyclic tetrapeptide scaffolds. The cyclic α-tetrapeptide ryclo(-Phe-D-Pro-Lys-Phe-) (1) and its four mixed analogues, having one of the α-Phe replaced by either an (S)- or an (R)-β2hPhe...