Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity

Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity

To discover antimalarial substances from plants cultivated in Thailand 80%-EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum. In total, 86 Thai medicinal plant samples representing 48 species from 35 gene...

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Main Authors: C. Ichino, N. Soonthornchareonnon, W. Chuakul, H. Kiyohara, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, S. Omura, Haruki Yamada
Other Authors: Kitasato University
Format: Article
Published: 2018
Subjects:
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/23172
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Institution: Mahidol University
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spelling th-mahidol.231722018-08-20T14:25:04Z Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity C. Ichino N. Soonthornchareonnon W. Chuakul H. Kiyohara A. Ishiyama H. Sekiguchi M. Namatame K. Otoguro S. Omura Haruki Yamada Kitasato University Mahidol University The Kitasato Institute Chemistry Pharmacology, Toxicology and Pharmaceutics To discover antimalarial substances from plants cultivated in Thailand 80%-EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum. In total, 86 Thai medicinal plant samples representing 48 species from 35 genera in 16 families were screened and two species (Polyalthia viridis and Goniothalamus marcanii) were found to show notable antimalarial activity (IC50: 10.0 and 6.3 μg/mL). Marcanine A and 16-hydroxycleroda-3,13(14)Z-dien-15,16- olide were identified as the respective major active constituents in P. viridis and G. marcanii, respectively. Copyright © 2006 John Wiley & Sons, Ltd. 2018-08-20T06:56:17Z 2018-08-20T06:56:17Z 2006-04-01 Article Phytotherapy Research. Vol.20, No.4 (2006), 307-309 10.1002/ptr.1850 10991573 0951418X 2-s2.0-33645899625 https://repository.li.mahidol.ac.th/handle/123456789/23172 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645899625&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemistry
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Chemistry
Pharmacology, Toxicology and Pharmaceutics
C. Ichino
N. Soonthornchareonnon
W. Chuakul
H. Kiyohara
A. Ishiyama
H. Sekiguchi
M. Namatame
K. Otoguro
S. Omura
Haruki Yamada
Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
description To discover antimalarial substances from plants cultivated in Thailand 80%-EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum. In total, 86 Thai medicinal plant samples representing 48 species from 35 genera in 16 families were screened and two species (Polyalthia viridis and Goniothalamus marcanii) were found to show notable antimalarial activity (IC50: 10.0 and 6.3 μg/mL). Marcanine A and 16-hydroxycleroda-3,13(14)Z-dien-15,16- olide were identified as the respective major active constituents in P. viridis and G. marcanii, respectively. Copyright © 2006 John Wiley & Sons, Ltd.
author2 Kitasato University
author_facet Kitasato University
C. Ichino
N. Soonthornchareonnon
W. Chuakul
H. Kiyohara
A. Ishiyama
H. Sekiguchi
M. Namatame
K. Otoguro
S. Omura
Haruki Yamada
format Article
author C. Ichino
N. Soonthornchareonnon
W. Chuakul
H. Kiyohara
A. Ishiyama
H. Sekiguchi
M. Namatame
K. Otoguro
S. Omura
Haruki Yamada
author_sort C. Ichino
title Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
title_short Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
title_full Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
title_fullStr Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
title_full_unstemmed Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
title_sort screening of thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/23172
_version_ 1763488777669443584

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