Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei
Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manife...
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th-mahidol.233452018-08-20T14:02:10Z Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei W. Joost Wiersinga Tom van der Poll Nicholas J. White Nicholas P. Day Sharon J. Peacock Academic Medical Centre, University of Amsterdam Mahidol University Nuffield Department of Clinical Medicine Immunology and Microbiology Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manifestations, with melioidosis septic shock being the most severe. Eradication of the organism following infection is difficult, with a slow fever-clearance time, the need for prolonged antibiotic therapy and a high rate of relapse if therapy is not completed. Mortality from melioidosis septic shock remains high despite appropriate antimicrobial therapy. Prevention of disease and a reduction in mortality and the rate of relapse are priority areas for future research efforts. Studying how the disease is acquired and the host -pathogen interactions involved will underpin these efforts; this review presents an overview of current knowledge in these areas, highlighting key topics for evaluation. © 2006 Nature Publishing Group. 2018-08-20T07:02:10Z 2018-08-20T07:02:10Z 2006-04-01 Review Nature Reviews Microbiology. Vol.4, No.4 (2006), 272-282 10.1038/nrmicro1385 17401526 2-s2.0-33645065888 https://repository.li.mahidol.ac.th/handle/123456789/23345 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645065888&origin=inward |
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Immunology and Microbiology W. Joost Wiersinga Tom van der Poll Nicholas J. White Nicholas P. Day Sharon J. Peacock Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
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Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manifestations, with melioidosis septic shock being the most severe. Eradication of the organism following infection is difficult, with a slow fever-clearance time, the need for prolonged antibiotic therapy and a high rate of relapse if therapy is not completed. Mortality from melioidosis septic shock remains high despite appropriate antimicrobial therapy. Prevention of disease and a reduction in mortality and the rate of relapse are priority areas for future research efforts. Studying how the disease is acquired and the host -pathogen interactions involved will underpin these efforts; this review presents an overview of current knowledge in these areas, highlighting key topics for evaluation. © 2006 Nature Publishing Group. |
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Academic Medical Centre, University of Amsterdam |
author_facet |
Academic Medical Centre, University of Amsterdam W. Joost Wiersinga Tom van der Poll Nicholas J. White Nicholas P. Day Sharon J. Peacock |
format |
Review |
author |
W. Joost Wiersinga Tom van der Poll Nicholas J. White Nicholas P. Day Sharon J. Peacock |
author_sort |
W. Joost Wiersinga |
title |
Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
title_short |
Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
title_full |
Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
title_fullStr |
Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
title_full_unstemmed |
Melioidosis: Insights into the pathogenicity of Burkholderia pseudomallei |
title_sort |
melioidosis: insights into the pathogenicity of burkholderia pseudomallei |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/23345 |
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1763495535645294592 |