Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum

• Main Authors: Kristen M. Massimine, Michael T. McIntosh, Lanxuan T. Doan, Chloé E. Atreya, Stephan Gromer, Worachart Sirawaraporn, David A. Elliott, Keith A. Joiner, R. Heiner Schirmer, Karen S. Anderson
• Other Authors: Yale University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23633
• Institution: Mahidol University

4′,5′-Dibromo-2′,7′-dinitrofluorescein, a red dye commonly referred to as eosin B, inhibits Toxoplasma gondii in both enzymatic and cell culture studies with a 50% inhibitory concentration (IC50) of 180 μM. As a non-active-site inhibitor of the bifunctional T. gondii dihydrofolate reductase-thymidyl...