Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon

• Main Authors: Swati B. Gupta, Christopher T. Mast, Nathan D. Wolfe, Vlad Novitsky, Sheri A. Dubey, Esper G. Kallas, Mauro Schechter, Bernard Mbewe, Eftyhia Vardas, Punee Pitisuttithum, Donald Burke, Dan Freed, Robin Mogg, Paul M. Coplan, Jon H. Condra, Romnie S. Long, Kiersten Anderson, Danilo R. Casimiro, John W. Shiver, Walter L. Straus
• Other Authors: Merck & Co., Inc.
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23745
• Institution: Mahidol University

An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B...