Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon
An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B...
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th-mahidol.237452018-08-20T14:16:43Z Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon Swati B. Gupta Christopher T. Mast Nathan D. Wolfe Vlad Novitsky Sheri A. Dubey Esper G. Kallas Mauro Schechter Bernard Mbewe Eftyhia Vardas Punee Pitisuttithum Donald Burke Dan Freed Robin Mogg Paul M. Coplan Jon H. Condra Romnie S. Long Kiersten Anderson Danilo R. Casimiro John W. Shiver Walter L. Straus Merck & Co., Inc. Johns Hopkins Bloomberg School of Public Health Harvard School of Public Health Universidade Federal de Sao Paulo Universidade Federal do Rio de Janeiro Malawi College of Medicine Ministry of Population and Health University of Witwatersrand Mahidol University Intl. Partnership for Microbicides Merck Research Laboratories Medicine An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. Copyright © 2006 by Lippincott Williams & Wilkins. 2018-08-20T07:16:43Z 2018-08-20T07:16:43Z 2006-06-01 Article Journal of Acquired Immune Deficiency Syndromes. Vol.42, No.2 (2006), 135-139 10.1097/01.qai.0000223017.01568.e7 15254135 2-s2.0-33745092368 https://repository.li.mahidol.ac.th/handle/123456789/23745 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745092368&origin=inward |
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Medicine Swati B. Gupta Christopher T. Mast Nathan D. Wolfe Vlad Novitsky Sheri A. Dubey Esper G. Kallas Mauro Schechter Bernard Mbewe Eftyhia Vardas Punee Pitisuttithum Donald Burke Dan Freed Robin Mogg Paul M. Coplan Jon H. Condra Romnie S. Long Kiersten Anderson Danilo R. Casimiro John W. Shiver Walter L. Straus Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| description |
An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. Copyright © 2006 by Lippincott Williams & Wilkins. |
| author2 |
Merck & Co., Inc. |
| author_facet |
Merck & Co., Inc. Swati B. Gupta Christopher T. Mast Nathan D. Wolfe Vlad Novitsky Sheri A. Dubey Esper G. Kallas Mauro Schechter Bernard Mbewe Eftyhia Vardas Punee Pitisuttithum Donald Burke Dan Freed Robin Mogg Paul M. Coplan Jon H. Condra Romnie S. Long Kiersten Anderson Danilo R. Casimiro John W. Shiver Walter L. Straus |
| format |
Article |
| author |
Swati B. Gupta Christopher T. Mast Nathan D. Wolfe Vlad Novitsky Sheri A. Dubey Esper G. Kallas Mauro Schechter Bernard Mbewe Eftyhia Vardas Punee Pitisuttithum Donald Burke Dan Freed Robin Mogg Paul M. Coplan Jon H. Condra Romnie S. Long Kiersten Anderson Danilo R. Casimiro John W. Shiver Walter L. Straus |
| author_sort |
Swati B. Gupta |
| title |
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| title_short |
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| title_full |
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| title_fullStr |
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| title_full_unstemmed |
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
| title_sort |
cross-clade reactivity of hiv-1-specific t-cell responses in hiv-1-infected individuals from botswana and cameroon |
| publishDate |
2018 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/23745 |
| _version_ |
1763492478078418944 |