The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by αVβ3 integrin in human breast cancer cells

• Main Authors: Kulrut Borrirukwanit, Marc A. Lafleur, Francesca A. Mercuri, Tony Blick, John T. Price, Rafael Fridman, Joseph J. Pereira, Vijittra Leardkamonkarn, Erik W. Thompson
• Other Authors: University of Melbourne
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24203
• Institution: Mahidol University

The influence of αVβ3 integrin on MT1-MMP functionality was studied in human breast cancer cells of differing β3 integrin status. Overexpression of β3 integrin caused increased cell surface expression of αV integrin and increased cellular adhesion to extracellular matrix (ECM) substrates in BT-549,...