Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study
Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endog...
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th-mahidol.242442018-08-24T09:13:46Z Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study Soo Heon Park Chul Soo Cho Oh Young Lee Jae Bum Jun San Ren Lin Li Ya Zhou Yao Zong Yuan Zhao Shen Li Xiao Hua Hou Hong Chuan Zhao Udom Kachintorn Chomsri Kositchaiwat Comson Lertkupinit The Catholic University of Korea Hanyang University Peking University Shanghai Second Medical University Changhai Hospital Huazhong University of Science and Technology China-Japan Friendship Hospital Mahidol University Chonburi Regional Hospital Biochemistry, Genetics and Molecular Biology Medicine Nursing Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal complications is unknown. The aim of this study was to compare NSAID-induced gastrointestinal complications in rebamipide- and misoprostol-treated groups. Patients were randomized to two groups and took a conventional NSAID plus rebamipide or misoprostol for 12 weeks. Gastric mucosal damage was evaluated by endoscopy at screening and the end of the study. The prevalences of active gastric ulcer were 7/176 (3.9%) in the rebamipide group and 3/156 (1.9%) in the misoprostol group. The prevalences of peptic ulcer were 8/176 (4.5%) in the rebamipide group and 7/156 (4.4%) in the misoprostol group. The cumulative incidences of peptic ulcer in the high-risk subgroup were 6/151 (4.0%) for rebamipide and 6/154 (3.9%) for misoprostol. In conclusion, rebamipide prevented NSAID-induced peptic ulcer as effectively as misoprostol in patients on long-term NSAID therapy. Rebamipide may be a useful therapeutic option for the prevention of NSAID-induced gastrointestinal ulcer because of its therapeutic effect and safety. 2018-08-24T01:43:07Z 2018-08-24T01:43:07Z 2007-03-01 Article Journal of Clinical Biochemistry and Nutrition. Vol.40, No.2 (2007), 148-155 10.3164/jcbn.40.148 09120009 2-s2.0-34247258850 https://repository.li.mahidol.ac.th/handle/123456789/24244 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247258850&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Nursing Soo Heon Park Chul Soo Cho Oh Young Lee Jae Bum Jun San Ren Lin Li Ya Zhou Yao Zong Yuan Zhao Shen Li Xiao Hua Hou Hong Chuan Zhao Udom Kachintorn Chomsri Kositchaiwat Comson Lertkupinit Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
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Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal complications is unknown. The aim of this study was to compare NSAID-induced gastrointestinal complications in rebamipide- and misoprostol-treated groups. Patients were randomized to two groups and took a conventional NSAID plus rebamipide or misoprostol for 12 weeks. Gastric mucosal damage was evaluated by endoscopy at screening and the end of the study. The prevalences of active gastric ulcer were 7/176 (3.9%) in the rebamipide group and 3/156 (1.9%) in the misoprostol group. The prevalences of peptic ulcer were 8/176 (4.5%) in the rebamipide group and 7/156 (4.4%) in the misoprostol group. The cumulative incidences of peptic ulcer in the high-risk subgroup were 6/151 (4.0%) for rebamipide and 6/154 (3.9%) for misoprostol. In conclusion, rebamipide prevented NSAID-induced peptic ulcer as effectively as misoprostol in patients on long-term NSAID therapy. Rebamipide may be a useful therapeutic option for the prevention of NSAID-induced gastrointestinal ulcer because of its therapeutic effect and safety. |
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The Catholic University of Korea |
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The Catholic University of Korea Soo Heon Park Chul Soo Cho Oh Young Lee Jae Bum Jun San Ren Lin Li Ya Zhou Yao Zong Yuan Zhao Shen Li Xiao Hua Hou Hong Chuan Zhao Udom Kachintorn Chomsri Kositchaiwat Comson Lertkupinit |
format |
Article |
author |
Soo Heon Park Chul Soo Cho Oh Young Lee Jae Bum Jun San Ren Lin Li Ya Zhou Yao Zong Yuan Zhao Shen Li Xiao Hua Hou Hong Chuan Zhao Udom Kachintorn Chomsri Kositchaiwat Comson Lertkupinit |
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Soo Heon Park |
title |
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
title_short |
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
title_full |
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
title_fullStr |
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
title_full_unstemmed |
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM study |
title_sort |
comparison of prevention of nsaid-induced gastrointestinal complications by rebamipide and misoprostol: a randomized, multicenter, controlled trial - storm study |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/24244 |
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1763493785761742848 |