Reactivity of chlorinating agents/PPh<inf>3</inf>for the chlorination of alcohols and carboxylic acids: a comparative study

Reactivity of chlorinating agents/PPh<inf>3</inf>for the chlorination of alcohols and carboxylic acids: a comparative study

The reactivity of chlorinating agents was examined with the aid of1H NMR using competitive reactions between selected chlorinating agents and CBr4towards alcohols and carboxylic acids. The reactivity was greatly dependent on the type of substituent on the chlorinating agents. COCCl3and CN substitute...

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Bibliographic Details
Main Authors: Wanchai Pluempanupat, Oraphin Chantarasriwong, Piyada Taboonpong, Doo Ok Jang, Warinthorn Chavasiri
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24267
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Institution: Mahidol University
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Summary:The reactivity of chlorinating agents was examined with the aid of1H NMR using competitive reactions between selected chlorinating agents and CBr4towards alcohols and carboxylic acids. The reactivity was greatly dependent on the type of substituent on the chlorinating agents. COCCl3and CN substituted trichloromethyl groups enhanced the reactivity of the chlorinating agent with PPh3for the chlorination of alcohols and carboxylic acids. © 2006 Elsevier Ltd. All rights reserved.

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