Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug...
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th-mahidol.245112018-08-24T09:01:00Z Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development Ernest Beutler Stephan Duparc Ogobara Doumbo Kanjaksha Ghosh Marcus Vinicius Guimaraes De Lacerda Didier Lapierre Sornchai Looareesuwan Zulfiqarali Premji Tom Vulliamy Christopher Whitty Scripps Research Institute International Center Cointrin University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology Institute of Immunohaematology Mumbai Fundacao de Medicina Tropical do Amazonas GlaxoSmithKline plc. Mahidol University University of Dar Es Salaam Imperial College London London School of Hygiene & Tropical Medicine Immunology and Microbiology Medicine Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug-induced G6PD deficiency-related hemolysis depends on a number of factors including the G6PD variant, the drug and drug dosage schedule, patient status, and disease factors. Although a great deal is known about the molecular biology of G6PD, determining the potential for drug-induced hemolysis in the clinical setting is still challenging. This report discusses the potential strategies for assessing drug-induced G6PD deficiency-related hemolytic risk preclinically and in early clinical trials. Additionally, the issues important for conducting larger clinical trials in populations in which G6PD deficiency is prevalent are examined, with a particular focus on antimalarial drug development. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene. 2018-08-24T01:51:51Z 2018-08-24T01:51:51Z 2007-10-01 Review American Journal of Tropical Medicine and Hygiene. Vol.77, No.4 (2007), 779-789 00029637 2-s2.0-38449090020 https://repository.li.mahidol.ac.th/handle/123456789/24511 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=38449090020&origin=inward |
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Immunology and Microbiology Medicine Ernest Beutler Stephan Duparc Ogobara Doumbo Kanjaksha Ghosh Marcus Vinicius Guimaraes De Lacerda Didier Lapierre Sornchai Looareesuwan Zulfiqarali Premji Tom Vulliamy Christopher Whitty Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug-induced G6PD deficiency-related hemolysis depends on a number of factors including the G6PD variant, the drug and drug dosage schedule, patient status, and disease factors. Although a great deal is known about the molecular biology of G6PD, determining the potential for drug-induced hemolysis in the clinical setting is still challenging. This report discusses the potential strategies for assessing drug-induced G6PD deficiency-related hemolytic risk preclinically and in early clinical trials. Additionally, the issues important for conducting larger clinical trials in populations in which G6PD deficiency is prevalent are examined, with a particular focus on antimalarial drug development. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene. |
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Scripps Research Institute |
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Scripps Research Institute Ernest Beutler Stephan Duparc Ogobara Doumbo Kanjaksha Ghosh Marcus Vinicius Guimaraes De Lacerda Didier Lapierre Sornchai Looareesuwan Zulfiqarali Premji Tom Vulliamy Christopher Whitty |
format |
Review |
author |
Ernest Beutler Stephan Duparc Ogobara Doumbo Kanjaksha Ghosh Marcus Vinicius Guimaraes De Lacerda Didier Lapierre Sornchai Looareesuwan Zulfiqarali Premji Tom Vulliamy Christopher Whitty |
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Ernest Beutler |
title |
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
title_short |
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
title_full |
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
title_fullStr |
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
title_full_unstemmed |
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
title_sort |
glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/24511 |
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1763495136926367744 |