Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development

• Main Authors: Ernest Beutler, Stephan Duparc, Ogobara Doumbo, Kanjaksha Ghosh, Marcus Vinicius Guimaraes De Lacerda, Didier Lapierre, Sornchai Looareesuwan, Zulfiqarali Premji, Tom Vulliamy, Christopher Whitty
• Other Authors: Scripps Research Institute
• Format: Review
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24511
• Institution: Mahidol University

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug...