Importance of collection tube during clinical studies of oseltamivir

Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step...

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Bibliographic Details
Main Authors: Niklas Lindegardh, Geraint R. Davies, Tinh Hien Tran, Jeremy Farrar, Pratap Singhasivanon, Nicholas P J Day, Nicholas J. White
Other Authors: Mahidol University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24916
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Institution: Mahidol University