Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils

• Main Authors: Kittipong Maneechotesuwan, Sarah Essilfie-Quaye, Sergei A. Kharitonov, Ian M. Adcock, Peter J. Barnes
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25044

Background: The role of neutrophils in exacerbations of asthma is poorly understood. We examined the effect of withdrawal of inhaled corticosteroids on sputum inflammatory indexes in a double-blind study in patients with moderate, stable asthma. Methods: Following a 2-week run in period, 24 subjects...