Differential stability of the mRNA secondary structures in the frameshift site of various HIV type 1 viruses

• Main Authors: Sui Yuan Chang, Ruengpung Sutthent, Prasert Auewarakul, Chatchawann Apichartpiyakul, Max Essex, Tun Hou Lee
• Other Authors: Harvard School of Public Health
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25424
• Institution: Mahidol University

For many retroviruses, one or more ribosomal frameshift events are required for translation of the Gag-Pol precursor protein, which is subsequently processed into the structural and enzymatic proteins found in mature virions. A specific nucleotide motif, the slippery sequence, as well as a downstrea...