Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, I...
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th-mahidol.254912018-09-07T15:53:03Z Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis Fanny N. Lauw Andrew J.H. Simpson Jan M. Prins Michael D. Smith Masashi Kurimoto Sander J.H. Van Deventer Peter Speelman Wipada Chaowagul Nicholas J. White Tom Van Der Poll Academic Medical Centre, University of Amsterdam Mahidol University Sappasitthiprasong Hospital Nuffield Department of Clinical Medicine Hayashibara Group Medicine Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia pseudomallei, of whom 12 died. Compared with healthy controls, patients had elevated levels of [FN-γ, IL-18, IL-12p40, and IL-15 on admission, with significantly higher levels in blood culture-positive patients, and these levels remained elevated during the 72-h study period. In whole blood stimulated with heat-killed B. pseudomallei, anti-IL-12 had a stronger inhibitory effect than anti-IL-18 and anti-IL-15 on IFN-γ production. This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-γ production is controlled at least in part by endogenous IL-18, IL-12, and IL-15. 2018-09-07T08:53:03Z 2018-09-07T08:53:03Z 1999-12-17 Article Journal of Infectious Diseases. Vol.180, No.6 (1999), 1878-1885 10.1086/315155 00221899 2-s2.0-0032708938 https://repository.li.mahidol.ac.th/handle/123456789/25491 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032708938&origin=inward |
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Medicine Fanny N. Lauw Andrew J.H. Simpson Jan M. Prins Michael D. Smith Masashi Kurimoto Sander J.H. Van Deventer Peter Speelman Wipada Chaowagul Nicholas J. White Tom Van Der Poll Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
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Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia pseudomallei, of whom 12 died. Compared with healthy controls, patients had elevated levels of [FN-γ, IL-18, IL-12p40, and IL-15 on admission, with significantly higher levels in blood culture-positive patients, and these levels remained elevated during the 72-h study period. In whole blood stimulated with heat-killed B. pseudomallei, anti-IL-12 had a stronger inhibitory effect than anti-IL-18 and anti-IL-15 on IFN-γ production. This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-γ production is controlled at least in part by endogenous IL-18, IL-12, and IL-15. |
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Academic Medical Centre, University of Amsterdam |
author_facet |
Academic Medical Centre, University of Amsterdam Fanny N. Lauw Andrew J.H. Simpson Jan M. Prins Michael D. Smith Masashi Kurimoto Sander J.H. Van Deventer Peter Speelman Wipada Chaowagul Nicholas J. White Tom Van Der Poll |
format |
Article |
author |
Fanny N. Lauw Andrew J.H. Simpson Jan M. Prins Michael D. Smith Masashi Kurimoto Sander J.H. Van Deventer Peter Speelman Wipada Chaowagul Nicholas J. White Tom Van Der Poll |
author_sort |
Fanny N. Lauw |
title |
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
title_short |
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
title_full |
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
title_fullStr |
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
title_full_unstemmed |
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis |
title_sort |
elevated plasma concentrations of interferon (ifn)-γ and the ifn-γ- inducing cytokines interleukin (il)-18, il-12, and il-15 in severe melioidosis |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/25491 |
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1763487888918446080 |