Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis

• Main Authors: Fanny N. Lauw, Andrew J.H. Simpson, Jan M. Prins, Michael D. Smith, Masashi Kurimoto, Sander J.H. Van Deventer, Peter Speelman, Wipada Chaowagul, Nicholas J. White, Tom Van Der Poll
• Other Authors: Academic Medical Centre, University of Amsterdam
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25491
• Institution: Mahidol University

Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, I...