An antimalarial stilbene from Artocarpus integer

An antimalarial stilbene from Artocarpus integer

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- is...

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Bibliographic Details
Main Authors: Choosak Boonlaksiri, Worrapoj Oonanant, Palangpon Kongsaeree, Prasat Kittakoop, Morakot Tanticharoen, Yodhathai Thebtaranonth
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/25797
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Institution: Mahidol University
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Summary:Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2- (2,4-dihydroxy)phenyl-trans-ethenyl)chromene, were also isolated. Structures of these compounds were deduced on the basis of their spectral data. (C) 2000 Elsevier Science Ltd.

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