An antimalarial stilbene from Artocarpus integer

• Main Authors: Choosak Boonlaksiri, Worrapoj Oonanant, Palangpon Kongsaeree, Prasat Kittakoop, Morakot Tanticharoen, Yodhathai Thebtaranonth
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25797

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E- but-1-enyl)-3,5,2',4'- tetrahydroxystilbene with an EC50of 1.7 μg/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4- is...