Fake artesunate in southeast Asia
Artesunate is a key antimalarial drug in the treatment of multidrug-resistant Plasmodium falciparum malaria in southeast Asia. We investigated the distribution of counterfeit artesunate tablets by use of the validated, simple, and inexpensive Fast Red TR dye technique. We also aimed to identify dist...
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th-mahidol.267572018-09-07T16:47:51Z Fake artesunate in southeast Asia Paul Newton Stephane Proux Michael Green Frank Smithuis Jan Rozendaal Sompol Prakongpan Kesinee Chotivanich Mayfong Mayxay Sornchai Looareesuwan Jeremy Farrar Francois Nosten Nicholas J. White Mahidol University John Radcliffe Hospital Shoklo Malaria Research Unit Centers for Disease Control and Prevention Médecins Sans Frontieres (Netherlands) Centre for Tropical Diseases Vietnam European Commission/Cambodia Malaria Control Project Medicine Artesunate is a key antimalarial drug in the treatment of multidrug-resistant Plasmodium falciparum malaria in southeast Asia. We investigated the distribution of counterfeit artesunate tablets by use of the validated, simple, and inexpensive Fast Red TR dye technique. We also aimed to identify distinguishing characteristics of the fake drugs. Of 104 shop-bought "artesunate" samples from Cambodia, Laos, Myanmar (Burma), Thailand, and Vietnam, 38% did not contain artesunate. Characteristics such as cost and physical appearance of the tablets and packaging reliably predicted authenticity. The illicit trade in counterfeit antimalarials is a great threat to the lives of patients with malaria. The dye test will assist national malaria control authorities in urgently needed campaigns to stop this murderous trade. 2018-09-07T09:47:51Z 2018-09-07T09:47:51Z 2001-06-16 Article Lancet. Vol.357, No.9272 (2001), 1948-1950 10.1016/S0140-6736(00)05085-6 01406736 2-s2.0-0035897913 https://repository.li.mahidol.ac.th/handle/123456789/26757 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035897913&origin=inward |
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Medicine Paul Newton Stephane Proux Michael Green Frank Smithuis Jan Rozendaal Sompol Prakongpan Kesinee Chotivanich Mayfong Mayxay Sornchai Looareesuwan Jeremy Farrar Francois Nosten Nicholas J. White Fake artesunate in southeast Asia |
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Artesunate is a key antimalarial drug in the treatment of multidrug-resistant Plasmodium falciparum malaria in southeast Asia. We investigated the distribution of counterfeit artesunate tablets by use of the validated, simple, and inexpensive Fast Red TR dye technique. We also aimed to identify distinguishing characteristics of the fake drugs. Of 104 shop-bought "artesunate" samples from Cambodia, Laos, Myanmar (Burma), Thailand, and Vietnam, 38% did not contain artesunate. Characteristics such as cost and physical appearance of the tablets and packaging reliably predicted authenticity. The illicit trade in counterfeit antimalarials is a great threat to the lives of patients with malaria. The dye test will assist national malaria control authorities in urgently needed campaigns to stop this murderous trade. |
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Mahidol University |
author_facet |
Mahidol University Paul Newton Stephane Proux Michael Green Frank Smithuis Jan Rozendaal Sompol Prakongpan Kesinee Chotivanich Mayfong Mayxay Sornchai Looareesuwan Jeremy Farrar Francois Nosten Nicholas J. White |
format |
Article |
author |
Paul Newton Stephane Proux Michael Green Frank Smithuis Jan Rozendaal Sompol Prakongpan Kesinee Chotivanich Mayfong Mayxay Sornchai Looareesuwan Jeremy Farrar Francois Nosten Nicholas J. White |
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Paul Newton |
title |
Fake artesunate in southeast Asia |
title_short |
Fake artesunate in southeast Asia |
title_full |
Fake artesunate in southeast Asia |
title_fullStr |
Fake artesunate in southeast Asia |
title_full_unstemmed |
Fake artesunate in southeast Asia |
title_sort |
fake artesunate in southeast asia |
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2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/26757 |
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1763487361349451776 |