BRCA1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells

• Main Authors: Moltira Promkan, Guangming Liu, Pimpicha Patmasiriwat, Subhas Chakrabarty
• Other Authors: Southern Illinois University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27096
• Institution: Mahidol University

BRCA1 is a multifunctional tumor-suppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wild-type BRCA1 human breast cancer MCF-7 and MDA-MB-2...