Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus

Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus

A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by compariso...

Full description

Saved in:
Bibliographic Details
Main Authors: Nattha Ingavat, Jeffrey Dobereiner, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Other Authors: Center for Environmental Health
Format: Note
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/27114
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
Description
Summary:A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.

Similar Items