Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by compariso...
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th-mahidol.271142018-09-13T14:11:23Z Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Center for Environmental Health Brandeis University Mahidol University Chulabhorn Research Institute The Institute of Science and Technology for Research and Development, Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy. 2018-09-13T06:21:10Z 2018-09-13T06:21:10Z 2009-11-30 Note Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052 10.1021/np9003883 01633864 2-s2.0-73349134679 https://repository.li.mahidol.ac.th/handle/123456789/27114 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73349134679&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
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A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy. |
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Center for Environmental Health |
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Center for Environmental Health Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
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Note |
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Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
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Nattha Ingavat |
title |
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
title_short |
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
title_full |
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
title_fullStr |
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
title_full_unstemmed |
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus |
title_sort |
aspergillusol a, an α-glucosidase inhibitor from the marine-derived fungus aspergillus aculeatus |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/27114 |
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1763495497205547008 |