Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus

A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by compariso...

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Main Authors:	Nattha Ingavat, Jeffrey Dobereiner, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Other Authors:	Center for Environmental Health
Format:	Note
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/27114
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Institution:	Mahidol University

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spelling	th-mahidol.271142018-09-13T14:11:23Z Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Center for Environmental Health Brandeis University Mahidol University Chulabhorn Research Institute The Institute of Science and Technology for Research and Development, Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy. 2018-09-13T06:21:10Z 2018-09-13T06:21:10Z 2009-11-30 Note Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052 10.1021/np9003883 01633864 2-s2.0-73349134679 https://repository.li.mahidol.ac.th/handle/123456789/27114 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73349134679&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
description	A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.
author2	Center for Environmental Health
author_facet	Center for Environmental Health Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop
format	Note
author	Nattha Ingavat Jeffrey Dobereiner Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop
author_sort	Nattha Ingavat
title	Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
title_short	Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
title_full	Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
title_fullStr	Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
title_full_unstemmed	Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
title_sort	aspergillusol a, an α-glucosidase inhibitor from the marine-derived fungus aspergillus aculeatus
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/27114
_version_	1763495497205547008

Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus

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