Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae

• Main Authors: Wachirasak Wangkangwan, Saipin Boonkerd, Warinthorn Chavasiri, Kasama Sukapirom, Kovit Pattanapanyasat, Ngampong Kongkathip, Tokichi Miyakawa
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27158
• Institution: Mahidol University

Upon searching plant extracts for inhibitors of the Ca2+signaling pathway using the zds1δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as acti...