Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae

Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae

Upon searching plant extracts for inhibitors of the Ca2+signaling pathway using the zds1δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as acti...

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Main Authors: Wachirasak Wangkangwan, Saipin Boonkerd, Warinthorn Chavasiri, Kasama Sukapirom, Kovit Pattanapanyasat, Ngampong Kongkathip, Tokichi Miyakawa
Other Authors: Chulalongkorn University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/27158
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spelling th-mahidol.271582018-09-13T13:41:46Z Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae Wachirasak Wangkangwan Saipin Boonkerd Warinthorn Chavasiri Kasama Sukapirom Kovit Pattanapanyasat Ngampong Kongkathip Tokichi Miyakawa Chulalongkorn University Mahidol University Kasetsart University Hiroshima University Biochemistry, Genetics and Molecular Biology Chemistry Immunology and Microbiology Upon searching plant extracts for inhibitors of the Ca2+signaling pathway using the zds1δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca2+signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae. 2018-09-13T06:22:32Z 2018-09-13T06:22:32Z 2009-08-19 Article Bioscience, Biotechnology and Biochemistry. Vol.73, No.7 (2009), 1679-1682 10.1271/bbb.90114 13476947 09168451 2-s2.0-68649089277 https://repository.li.mahidol.ac.th/handle/123456789/27158 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68649089277&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Immunology and Microbiology
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Immunology and Microbiology
Wachirasak Wangkangwan
Saipin Boonkerd
Warinthorn Chavasiri
Kasama Sukapirom
Kovit Pattanapanyasat
Ngampong Kongkathip
Tokichi Miyakawa
Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
description Upon searching plant extracts for inhibitors of the Ca2+signaling pathway using the zds1δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca2+signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Wachirasak Wangkangwan
Saipin Boonkerd
Warinthorn Chavasiri
Kasama Sukapirom
Kovit Pattanapanyasat
Ngampong Kongkathip
Tokichi Miyakawa
format Article
author Wachirasak Wangkangwan
Saipin Boonkerd
Warinthorn Chavasiri
Kasama Sukapirom
Kovit Pattanapanyasat
Ngampong Kongkathip
Tokichi Miyakawa
author_sort Wachirasak Wangkangwan
title Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
title_short Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
title_full Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
title_fullStr Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
title_full_unstemmed Pinostrobin from Boesenbergia pandurata Is an inhibitor of Ca 2+-Signal-Mediated Cell-Cycle regulation in the Yeast Saccharomyces cerevisiae
title_sort pinostrobin from boesenbergia pandurata is an inhibitor of ca 2+-signal-mediated cell-cycle regulation in the yeast saccharomyces cerevisiae
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/27158
_version_ 1763490372430856192

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