Pharmaco/ferrokinetic-related pro-oxidant activity of deferiprone in β-thalassemia

• Main Authors: Totsapol Jirasomprasert, Noppawan Phumala Morales, Lie M G Limenta, Srisuporn Sirijaroonwong, Paveena Yamanont, Prapin Wilairat, Suthat Fucharoen, Udom Chantharaksri
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27177

The potential of free radical formation in serum of β-thalassemia/ Hb E patients receiving a single oral dose of 25 mg/kg body weight of deferiprone, a bidentate orally active iron chelator, was evaluated using EPR/spin trapping technique. In the presence of ascorbic acid and tert-butylhydroperoxide...