Human monoclonal ScFv neutralize lethal Thai cobra, Naja kaouthia, neurotoxin

• Main Authors: Kasem Kulkeaw, Yuwaporn Sakolvaree, Potjanee Srimanote, Pongsri Tongtawe, Santi Maneewatch, Nitat Sookrung, Anchalee Tungtrongchitr, Pramuan Tapchaisri, Hisao Kurazono, Wanpen Chaicumpa
• Other Authors: Thammasat University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27268
• Institution: Mahidol University

Animal derived anti-Naja. kaouthia (Thai cobra) venom is used for specific treatment of the snake bitten victims. Many recipients develop allergic reaction or anti-isotype response which causes serum sickness. A better therapeutic antibody is needed. In this study, long α-neurotoxin was purified fro...