Therapeutic potential of splice-switching oligonucleotides

Alternative splicing enables a single pre-messenger RNA transcript to yield multiple protein isoforms, making it a major contributor to the diversity of the proteome. While this process is essential for normal development, aberrations in alternative splicing are the cause of a multitude of human dis...

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Bibliographic Details
Main Authors: John Bauman, Natee Jearawiriyapaisarn, Ryszard Kole
Other Authors: The University of North Carolina at Chapel Hill
Format: Review
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/27275
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Institution: Mahidol University